At Tentarix Biotherapeutics we are bringing powerful biology selectively to cell types that drive therapeutic benefit with multifunctional biologics that are manufacturable.

Powerful biology, such as that generated by growth factors, cytokines, and morphogens, can activate a cell, change the fate of a cell, make a cell proliferate, and even extend the life of a cell.  However, since this type of activity is rarely cell type specific, if administered systemically this activity not only impact cells that drive therapeutic benefit but also other cells that severely limit these benefits.

Most powerful biology works through combinations of two or more cell surface receptors, engaged in concert to activate a pathway.  The Tentarix multifunctional biologics selectively bind to these cell surface receptors along with other cell surface proteins, specific to the cell type of interest, so that only when targeted cell surface binding conditions are met is the pathway activated.  

This targeted, conditional activity allows Tentarix to harness powerful biology and direct it to the cell type that drives therapeutic benefit.  This requires the screening of millions of molecules and a platform based on cell surface proteomics (CellSurf), binder generation (HuTARG), and combinatorial assembly and identification of multifunctional biologics (FunctionSeq).

Molecules that drive powerful biology, such as growth factors, cytokines, and morphogens, are also notoriously difficult to manufacture.  Tentarix multifunctional biologics are not based on natural ligands.  Rather, Tentarix molecules are based on fully human antibody components, which when combined, recapitulate powerful biology. Thus, their manufacturing is based on decades of robust, industrialized process development.

Tentacles™—Tentarix’s multifunctional biologics—are targeted, synergistic and conditional, which means they activate a target cell population only when all desired receptors are present.

At Tentarix, we break away from the traditional screening paradigm by sifting through millions of candidates upfront. That allows us to efficiently identify molecules that meet our multifunctional biologics criteria.

Multifunction
Biologics

Targeted

Targeted cell surface proteins enable selectivity with desired function

Synergistic

Cell surface proteins that, when combined, act synergistically

Conditional

There is only biological activity in a cell when all targets are engaged

Our proprietary method for quantification of cell surface protein expression to identify the ideal receptor combinations.

Our innovative mammalian display system for antibody variable domains harnesses nature’s most powerful diversity engine, VDJ recombination, to generate functional binding units.

Rapid combinatorial assembly of millions of potential multifunctional molecules, followed by empirical selection directly for conditional functional activity.

Programs

Not only are Tentacleshighly-effective multifunctional biologics, the Tentacles platform is modular, so it can be used to create biologics that treat a range of diseases. The classes of molecules or pathways currently in the pipeline include T cell co-agonists, regulatory T cell reprogramming, cell-specific internalizers, and T cell activators. Tentarix looks forward to the seemingly endless opportunities this platform brings.

Our leading program activates IL2R specifically on tumor-reactive T cells in the tumor-microenvironment using a combination of receptors chosen for selectivity and function. The leading Tentacles are designed to activate and expand tumor-reactive T cells while enhancing their effector capabilities and metabolic fitness through a synergistic secondary signal.

  • Biotechnology company Tentarix Biotherapeutics LP today announced a $50 million Series A investment co-led by Versant Ventures and Samsara BioCapital. Read the full story

Tentarix Biotherapeutics is led by an executive team with years—often decades—of expertise in the field of multifunctional drug discovery. We are looking to hire highly-qualified, motivated individuals who, like us, want to revolutionize the disease therapy landscape.

Tentarix team members are creative, self-driven, and team-oriented. They’re also effective communicators determined to contribute to the company’s success. 

We know that our employees are our most valuable asset, so we provide desirable benefits and compensation accordingly. And we offer a modern, flexible work culture with the tools to ensure that we succeed not only as individuals but as a collective. 

Tentarix is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

Tentarix Biotherapeutics, Inc. also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. We are an E-Verify employer.