Introducing the
Tentacles™ platform
Our Platform Relies on
Three Critical Pillars
CellSurf™
Defining Key Features of Cells Involved in Disease
Understanding cell surface proteomes in healthy and diseased cells
HuTARG™
Discovering Tentacle Components
Encompassing the human immune system within a mammalian display platform for fully human binder discovery
FunctionSeq™
Tailoring Specific Agonists
Employing a function-first platform to create and screen millions of Tentacles
Identifying suitable targets is a complex task; numerous attempts are made to discover novel targets exhibiting specific traits (e.g., abundant in tumors, absent in normal tissue).
Tentarix has the capability to analyze human tissue samples, both diseased and normal, to pinpoint desired target combinations ensuring heightened specificity within the intended tissue.
CellSurf™
Defining Key Features of Cells Involved in Disease
HuTARG™
Discovering Tentacle Components
VH-Select platform of computationally stabilized VH scaffolds representing the entire human VH repertoire
Leverages natural human antibody recombination to generate massive binder diversity while maintaining fully human characteristics
High throughput mammalian display platform for the discovery of novel binders from libraries of >1 billion unique VHs
Computational Stabilization of All Functional VH Domains in the Human Genome
Protein Expression Level
Protein Thermal Stability
Our novel VH domain stabilization enables Tentarix to uncover diverse epitopes efficiently during Binder Discovery campaigns, making it easy to find what matters most in creating effective therapeutics.
Prioritizing Functional Outcomes
Discovering Tentacles with optimal activity and cell specificity requires screening massive numbers (>1 million Tentacles) that are inaccessible to most screening platforms.
Tentarix leverages mammalian display to assess >1 million Tentacles, which provides the capacity to investigate:
Varied binder epitope and affinities of the individual binding components
Varied Tentacle geometries
Varied linker lengths
